Abstract
Various 3-H-1,5-benzodiazepines were prepared from the solvent-free reaction of o-phenylenediamine and substituted 1,3-diphenyl-1,3-propanedione, giving good yields of benzodiazepines. The H6P2W18O62.24H2O solid heteropolyacid, which possesses a Wells-Dawson type structure was used as catalyst both in bulk and silica-supported forms (0.1, 0.2, 0.4 and 0.6 g/g, named 0.1WDSiO2, 0.2WDSiO2, 0.4WDSiO2 and 0.6WDSiO2, respectively). The structure of the synthesized heteropolyacid was confirmed using different characterization techniques (FTIR; 31P-RMN, and potentiometric titration).
Keywords: Benzodiazepines, Green chemistry, Heterogeneous catalysis, Heteropolyacid, Solvent-free reaction, Wells-Dawson structure.
Current Catalysis
Title:Wells-Dawson Type Catalyst: An Efficient, Recoverable and Reusable Solid Acid Catalyst for the Solvent-Free Synthesis of Benzodiazepines
Volume: 3 Issue: 2
Author(s): Gustavo A. Pasquale, Diego M. Ruiz, Graciela T. Baronetti, Horacio J. Thomas, Juan C. Autino and Gustavo P. Romanelli
Affiliation:
Keywords: Benzodiazepines, Green chemistry, Heterogeneous catalysis, Heteropolyacid, Solvent-free reaction, Wells-Dawson structure.
Abstract: Various 3-H-1,5-benzodiazepines were prepared from the solvent-free reaction of o-phenylenediamine and substituted 1,3-diphenyl-1,3-propanedione, giving good yields of benzodiazepines. The H6P2W18O62.24H2O solid heteropolyacid, which possesses a Wells-Dawson type structure was used as catalyst both in bulk and silica-supported forms (0.1, 0.2, 0.4 and 0.6 g/g, named 0.1WDSiO2, 0.2WDSiO2, 0.4WDSiO2 and 0.6WDSiO2, respectively). The structure of the synthesized heteropolyacid was confirmed using different characterization techniques (FTIR; 31P-RMN, and potentiometric titration).
Export Options
About this article
Cite this article as:
Pasquale A. Gustavo, Ruiz M. Diego, Baronetti T. Graciela, Thomas J. Horacio, Autino C. Juan and Romanelli P. Gustavo, Wells-Dawson Type Catalyst: An Efficient, Recoverable and Reusable Solid Acid Catalyst for the Solvent-Free Synthesis of Benzodiazepines, Current Catalysis 2014; 3 (2) . https://dx.doi.org/10.2174/2211544702666131224003128
DOI https://dx.doi.org/10.2174/2211544702666131224003128 |
Print ISSN 2211-5447 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5455 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Understanding Non-Mendelian Genetic Risk
Current Genomics Cloning, Expression and Characterization of Mouse (Mus musculus) Nicotinamide 5-Mononucleotide Adenylyltransferase-2
Medicinal Chemistry Activation of Melanocortin-4 Receptor by a Synthetic Agonist Inhibits Ethanolinduced Neuroinflammation in Rats
Current Pharmaceutical Design Human Saliva Metabolome for Oral Lichen Planus Biomarker Identification
Recent Patents on Anti-Cancer Drug Discovery Management of Inflammation by Natural Polyphenols: A Comprehensive Mechanistic Update
Current Medicinal Chemistry Evolving Mechanistic Concepts of Epileptiform Synchronization and their Relevance in Curing Focal Epileptic Disorders
Current Neuropharmacology Effect of Stigmas of Crocus sativus L. (saffron) on Cell Mediated and Humoral Immunity
The Natural Products Journal Proteomics and Mass Spectrometry: What Have We Learned About The Heart?
Current Cardiology Reviews Tight Junctions of the Blood-Brain Barrier – A Molecular Gatekeeper
CNS & Neurological Disorders - Drug Targets Serotonin and Human Cognitive Performance
Current Pharmaceutical Design Emerging Drug Therapies and Site-Specific Interventions for Autoimmune Hepatitis
Medicinal Chemistry Reviews - Online (Discontinued) Effective Classification of Major Depressive Disorder Patients Using Machine Learning Techniques
Recent Patents on Computer Science DASH Dietary Pattern: A Treatment for Non-communicable Diseases
Current Hypertension Reviews Purification and Preliminary Crystallographic Studies of CutC, a Novel Copper Homeostasis Protein from Shigella flexneri
Protein & Peptide Letters New Bisquaternary Isoquinolinium Inhibitors of Brain Cholinesterases - Synthesis and Anticholinesterase Activity
Letters in Drug Design & Discovery Conclusive Article: Sorting the Good from the Bad: The Different Approaches to Predict Cognitive Properties of New Symptomatic Drug Candidates for Neurodegenerative Diseases in Early Development
CNS & Neurological Disorders - Drug Targets New Antiepileptic Drugs: Molecular Targets
Central Nervous System Agents in Medicinal Chemistry Tocilizumab in SARS-CoV-2 Patients with the Syndrome of Cytokine Storm: A Narrative Review
Reviews on Recent Clinical Trials Current Dental Adhesives Systems. A Narrative Review
Current Pharmaceutical Design Identification of Novel Quantitative Traits-Associated Susceptibility Loci for APOE ε 4 Non-Carriers of Alzheimer’s Disease
Current Alzheimer Research