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CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)
ISSN (Print): 1871-5273
ISSN (Online): 1996-3181
Epub Full Text Article
DOI: 10.2174/1871527312666131223114457      Price:  $95









Synaptic Activity-Regulated Wnt Signaling in Synaptic Plasticity, Glial Function and Chronic Pain

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Author(s): SJ Tang
Abstract:
Wnt signaling pathways are master regulatory networks in a variety of developmental and oncogenic processes. In the nervous system, Wnt signaling pathways are known to regulate neuronal morphogenesis and synaptic differentiation. Aberrant Wnt signaling is implicated in various neurological diseases. Recent studies have revealed that the activity of Wnt signaling pathways is critically controlled by synaptic activity. The activity-regulated Wnt signaling plays an important role in the expression of synaptic plasticity and memory formation. Dysregulation of the activity-regulated Wnt signaling may have a significant impact on the function of the nervous system. In this article, we will review the identified mechanisms by which synaptic activity controls Wnt signaling in neurons and the neurological functions of the activity-regulated Wnt signaling under normal and specific disease conditions. In particular, we will discuss the role of Wnt signaling in the pathogenesis of chronic pain
Keywords:
Wnt, pain, synapse, glia, synaptic plasticity, neuroinflammation, N-­‐methyl-­‐D-­‐aspartate, receptor, mammalian target of rapamycin, long-term potentiation, Human immunodeficiency virus-1
Affiliation:
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA