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CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)
ISSN (Print): 1871-5273
ISSN (Online): 1996-3181
Epub Full Text Article
DOI: 10.2174/1871527312666131223114149      Price:  $95

The Canonical Wnt Signaling Pathway in Autism

Author(s): Y Zhang, X Yuan, Z Wang and R Li
With continuous accumulation of research on the molecular pathogenesis of autism, more attention is being focused on the canonical Wnt signaling pathway. The canonical Wnt signaling pathway has been implicated in a variety of functions in the cell, including proliferation, differentiation, apoptosis and neuronal migration during embryonic development. Given its wide range of roles, dysregulation of the canonical Wnt signaling pathway could have any number of deleterious effects on neural development and thereby contribute to the pathogenesis of neurodevelopmental disorders, such as autism. Here, we review human and animal studies that implicate the canonical Wnt signal transduction pathway in the pathogenesis of autism. We also describe the crosstalk between the canonical Wnt pathway with the Notch signaling pathway in several types of autism spectrum disorders, including Asperger syndrome and Fragile X. Further research on the crosstalk between the canonical Wnt signaling pathway and other signaling cascades in autism may be an efficient avenue to understand the etiology of autism and ultimately lead to alternative medications for autism-like phenotypes
Autism, β-catenin, Notch, Signaling crosstalk, Wnt
Department of Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, Yixueyuan road 138, Shanghai 200032, China