CNS & Neurological Disorders - Drug Targets

(Formerly Current Drug Targets - CNS & Neurological Disorders)

Stephen D. Skaper  
Department of Pharmaceutical and Pharmacological Sciences
University of Padova


Wnt Signaling Pathway in Schizophrenia

Author(s): Yanmin Peng, Yifeng Xu and Donghong Cui

Affiliation: Key Laboratory of Translational Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 3210 Humin Rd, Shanghai, 200030, China.


The Wnt signaling pathway is one of the crucial signaling pathways that regulate many aspects of central nervous system. In this review, we tempt to depict an overall picture of the Wnt signaling with its multitude of roles in schizophrenia. If the Wnt signaling pathway plays a crucial role in the pathogenesis of schizophrenia as we suggest, a better understanding of the Wnt pathway might contribute to developing new and more effective tools for diagnosis and treatment of schizophrenia.

Keywords: Adenomatous polyposis coli, glycogen synthase kinase-3, schizophrenia, Wnt signaling pathway.

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Article Details

Page: [755 - 764]
Pages: 10
DOI: 10.2174/1871527312666131223113521