Wnt Signaling Pathway in Schizophrenia
Yanmin Peng, Yifeng Xu and Donghong Cui
Affiliation: Key Laboratory of Translational Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 3210 Humin Rd, Shanghai, 200030, China.
Keywords: Adenomatous polyposis coli, glycogen synthase kinase-3, schizophrenia, Wnt signaling pathway.
The Wnt signaling pathway is one of the crucial signaling pathways that regulate many aspects of central
nervous system. In this review, we tempt to depict an overall picture of the Wnt signaling with its multitude of roles in
schizophrenia. If the Wnt signaling pathway plays a crucial role in the pathogenesis of schizophrenia as we suggest, a
better understanding of the Wnt pathway might contribute to developing new and more effective tools for diagnosis and
treatment of schizophrenia.
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