Telomeres and their Role in Aging and Longevity
Irene P. Tzanetakou,
Despina N. Perrea,
Telomeres are DNA-protein structures that form protective caps at the end of eukaryotic chromosomes. They
constitute the safeguards of chromosome degradation and are responsible for maintaining genomic integrity. The
multifactorial nature of telomere length (TL) regulation increases the perplexity of studies in the field. TL is characterized
by a high variability among individuals (birth and later life) and among species but it is unknown whether this is
associated with their lifespan potential. TL is also highly heritable, longer in women than in men; it is highly variable
between tissues and organs and inversely related to chronological age. Accelerated telomere loss has been associated with
many chronic diseases of aging. Premature aging or cellular senescence, seen in early life, through increased oxidative
stress and DNA damage to telomeric ends may be initiators of processes related to these diseases. During the recent
decade, research around telomere biology has rapidly expanded due to its dynamic involvement in aging and longevity.
However, longevity is not necessarily an indication of disability-free aging. There is substantial scientific disagreement
and controversial results, regarding even the basic nature of aging and the path to longevity. We review the current
evidence linking telomere biology to aging processes and mechanisms leading to longevity.
Keywords: Aging, life span, longevity, telomerase, telomeres, telomere dynamics.
Rights & PermissionsPrintExport