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Current Vascular Pharmacology
ISSN (Print): 1570-1611
ISSN (Online): 1875-6212
Epub Abstract Ahead of Print
DOI: 10.2174/1570161111666131219113544      Price:  $95









Centenarian Offspring: a model for Understanding Longevity

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Author(s): Carmela Rita Balistreri, Giulia Accardi, Silvio Buffa, Matteo Bulati, Adriana Martorana, Giuseppina Candore, Giuseppina Colonna-Romano, Domenico Lio and Calogero Caruso
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Abstract:
A main objective of current medical research is the improving of life quality of elderly people as priority of the continuous increase of ageing population. This phenomenon implies several medical, economic and social problems because of dramatic increase in number of not autonomous individuals affected by various pathologies. Accordingly, the research interest is focused on understanding the biological mechanisms involved in determining the positive ageing phenotype, i.e. the centenarian phenotype. In achieving this goal the choice of an appropriate study models is fundamental. Centenarians have been used as an optimal model for successful ageing. However, it is characterized by several limitations, i.e. the selection of appropriate controls for centenarians and the use itself of the centenarians as a suitable model for healthy ageing. Thus, the interest has been centered on centenarian offspring, healthy elderly people. They may represent a model for understanding exceptional longevity for the following reasons: to exhibit a protective genetic background, cardiovascular and immunological profile as well as a reduced rate of cognitive decline than age-matched people without centenarian relatives. Several of these aspects are summarized in this review based on the literature and the results of our studies
Affiliation:
Gruppo di Studio sull'Immunosenescenza Dipartimento di Biopatologia e di Biotecnologie Mediche e Forensi Corso Tukory 211 90134 Palermo – Italy