Current Vascular Pharmacology

Dimitri P. Mikhailidis  
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG
UK

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Centenarian Offspring: A Model for Understanding Longevity

Author(s): Carmela Rita Balistreri, Giuseppina Candore, Giulia Accardi, Silvio Buffa, Matteo Bulati, Adriana Martorana, Giuseppina Colonna-Romano, Domenico Lio, Calogero Caruso.

Abstract:

A main objective of current medical research is to improve the life quality of elderly people as priority of the continuous increase of ageing population. This phenomenon implies several medical, economic and social problems because of dramatic increase in number of non autonomous individuals affected by various pathologies. Accordingly, the research interest is focused on understanding the biological mechanisms involved in determining the positive ageing phenotype, i.e. the centenarian phenotype. In achieving this goal the choice of an appropriate study models is fundamental. Centenarians have been used as an optimal model for successful ageing. However, this model shows several limitations, i.e. the selection of appropriate controls and the use itself of the centenarians as a suitable model for healthy ageing. Thus, the interest has been centered on centenarian offspring, healthy elderly people. They may represent a model for understanding exceptional longevity for the following reasons: they exhibit a protective genetic background, cardiovascular and immunological profile, as well as a reduced rate of cognitive decline than age-matched people without centenarian relatives. Several of these aspects are summarized in this review based on the literature and the results of our studies.

Keywords: Ageing, cardiovascular profile, centenarians, centenarian offspring, genetic background, immunosenescence, memory decline.

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2014
Page: [718 - 725]
Pages: 8
DOI: 10.2174/1570161111666131219113544
Price: $58