Current Analytical Chemistry

Samuel Achilefu
Washington University
St. Louis, MO
USA
Email: cac@benthamscience.org

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Derivatization Coupled to Chemiluminescence Detection

Author(s): George Z. Tsogas, Dimosthenis L. Giokas and Athanasios G. Vlessidis

Affiliation: Laboratory of Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece.

Keywords: Chemiluminescence, derivatization, liquid chromatography, capillary electrophoresis.

Graphical Abstract:


Abstract:

In this work, an overview of analytical methods employing derivatization reactions in chemiluminescence detection is presented. Method development, instrumental configurations and hyphenated manifolds, specifically designed or implemented to accommodate CL detection, along with their analytical applications for the determination of a wide variety of organic compounds such as biochemically active substances, pharmaceutical active compounds, environmental pollutants and food constituents, are summarized. The analytical merits of derivatization reactions in chemiluminescence analysis and their potential for the development of sensitive and selective methods are elucidated.

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Article Details

VOLUME: 10
ISSUE: 3
Page: [305 - 319]
Pages: 15
DOI: 10.2174/1573411010999131219101823