In this work, an overview of analytical methods employing derivatization reactions in chemiluminescence detection
is presented. Method development, instrumental configurations and hyphenated manifolds, specifically designed or
implemented to accommodate CL detection, along with their analytical applications for the determination of a wide variety
of organic compounds such as biochemically active substances, pharmaceutical active compounds, environmental pollutants
and food constituents, are summarized. The analytical merits of derivatization reactions in chemiluminescence
analysis and their potential for the development of sensitive and selective methods are elucidated.
Keywords: Chemiluminescence, derivatization, liquid chromatography, capillary electrophoresis.
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