Current Vascular Pharmacology

Dimitri P. Mikhailidis  
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG
UK

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Ageing Mechanisms and Associated Lipid Changes

Author(s): Genovefa Kolovou, Niki Katsiki, Antonis Pavlidis, Helen Bilianou, George Goumas and Dimitri P. Mikhailidis

Affiliation: Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece;.

Keywords: Ageing, genes, somatopause, total cholesterol, triglyceride.

Abstract:

Ageing is related to slowdown/breakdown of the somatotropic axis (i.e. the somatopause) leading to many physiological changes. The somatopause is accompanied by DNA and other macromolecule damage, and is characterized by a progressive decline in vitality and tissue function. We still do not have a definitive understanding of the mechanism( s) of ageing. Several overlapping theories have been proposed such as: 1) The free radical theory, 2) Mitochondrial Ageing, 3) The Glycation Theory, 4) Protein Damage and Maintenance in Ageing, and, 5) DNA Damage and Repair. Furthermore, several models of ageing were introduced such as genetically programmed senescence, telomere shortening, genomic instability, heterochromatin loss, altered epigenetic patterns and long lived cells. There are certain lipid modifications associated with the somatopause, characterized mainly by an increase in total cholesterol and triglyceride levels in both genders.

In this review we consider the mechanisms of ageing and the associated changes in lipid metabolism according to gender.

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Article Details

VOLUME: 12
ISSUE: 5
Page: [682 - 689]
Pages: 8
DOI: 10.2174/1570161111666131219094542