Mass spectrometry (MS) is one of the key analytical technology on which the emerging ‘‘-omics’’ approaches are based. It
may provide detection and quantization of thousands of proteins and biologically active metabolites from a tissue, body fluid or cell culture
working in a ‘‘global’’ or ‘‘targeted’’ manner, down to ultra-trace levels. It can be expected that the high performance of MS technology,
coupled to routine data handling, will soon bring fruit in the request for a better understanding of human diseases, leading to new
molecular biomarkers, hence affecting drug targets and therapies.
In this review, we focus on the main advances in the MS technologies, influencing genomics, transcriptomics, proteomics, lipidomics and
metabolomics fields, up to the most recent MS applications to meta-omic studies.