Naturally Occurring Calanolides: An Update on Their Anti-HIV Potential and Total Syntheses
Goutam Brahmachari and Shyamal K. Jash
Affiliation: Laboratory of Natural Products and Organic Synthesis, Department of Chemistry, Visva-Bharati University, Santiniketan-731 235, West-Bengal, India.
Calanolides are naturally occurring pyranocoumarins found particularly in Calophyllum species (family Clusiaceae/
Guttiferae), and are well known for their potent anti-human immunodeficiency virus (HIV) activity. Various preclinical
and clinical studies with this class of compounds are going on, and the National Cancer Institute (NCI) has been
playing an active and supportive role in this regard. The present review covers an up-to-date literature of naturally occurring
calanolides in view of their anti-HIV potential and total syntheses including information on related patents.
Keywords: Anti-HIV potential, Calophyllum sp., clusiaceae/guttiferae, natural abundance, natural calanolides, related patents,
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