Recent Patents on Biotechnology

Nikolaos Labrou
Laboratory of Enzyme Technology, Department of Biotechnology
Agricultural University of Athens Iera Odos 75, Gr-118 55


Naturally Occurring Calanolides: An Update on Their Anti-HIV Potential and Total Syntheses

Author(s): Goutam Brahmachari and Shyamal K. Jash

Affiliation: Laboratory of Natural Products and Organic Synthesis, Department of Chemistry, Visva-Bharati University, Santiniketan-731 235, West-Bengal, India.


Calanolides are naturally occurring pyranocoumarins found particularly in Calophyllum species (family Clusiaceae/ Guttiferae), and are well known for their potent anti-human immunodeficiency virus (HIV) activity. Various preclinical and clinical studies with this class of compounds are going on, and the National Cancer Institute (NCI) has been playing an active and supportive role in this regard. The present review covers an up-to-date literature of naturally occurring calanolides in view of their anti-HIV potential and total syntheses including information on related patents.

Keywords: Anti-HIV potential, Calophyllum sp., clusiaceae/guttiferae, natural abundance, natural calanolides, related patents, total syntheses.

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Article Details

Page: [3 - 16]
Pages: 14
DOI: 10.2174/1872208307666131218123753
Price: $100