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Anti-Infective Agents
Anti-Infective Agents in Medicinal Chemistry
ISSN (Print): 2211-3525
ISSN (Online): 2211-3533
Epub Full Text Article
DOI: 10.2174/2211352511999131217112945      Price:  $95

Phytochemical Analysis and Antibacterial Action of Indian Traditional Medicinal Plants

Author(s): Sandeep Dhankhar, Seema Dhankhar, Sonam Ruhil, Manish Kumar, Neetu Phougat, Meenakshi Balhara, Anu Singh and A.K. Chhillar
The biological properties of medicinal plants have been documented worldwide for many centuries. However, the top priority for the biomedical field is the search for safe and effective antibacterial agents against the wide variety of bacterial infections. Therefore, the present study aimed to evaluate various phytoconstituents and in-vitro antibacterial activity of crude extracts from Aegle marmelos, Capparis aphylla, Callistemon lanceolatus, Commelina bengalensis, Justicia adhatoda, Argemona mexicana, Achyranthes aspera, Catharanthus roseus and Syzygium cumini. The antibacterial activity of different solvent (Petroleum ether, Chloroform, Acetone, Methanol and water) extracts prepared from nine plants were screened against some reference strain of bacteria (Escherichia coli, Vibrio cholerae, Klebsiella pneumoniae, Proteus vulgaris, Bacillus subtilis, Salmonella typhi) by using resazurin based microtitre dilution assay and disc diffusion assay. The presence of phenols, tannins, flavanoids, terpenoid, steroids, alkaloids and saponins in the different extracts were established. A minimum inhibitory concentration of these bioactive extracts ranges from 6.00 to 0.37 mg/ml. In disc diffusion assay, at concentration of 25.0
Antibacterial, Drugs, Escherichia coli, Infections, Medicinal plants, Toxicity
Centre for Biotechnology, Maharshi Dayanand University, Rohtak -124001, Haryana, India