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Combinatorial Chemistry & High Throughput Screening
ISSN (Print): 1386-2073
ISSN (Online): 1875-5402
Epub Full Text Article
DOI: 10.2174/1386207316666131217104925      Price:  $95









One-Pot Multi-Component Route to Propargylamines Using Zinc Oxide Under Solvent-Free Conditions

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Author(s): Mona Hosseini-Sarvari and Fatemeh Moeini
Abstract:
In this paper, commercially available ZnO was found to be a highly effective catalyst for three-component coupling reactions of alkynes, aldehydes/or ketone and amines (A3-coupling) via C-H activation. The reactions could be applied to both aromatic and aliphatic aldehydes. Nearly quantitative yields of the desired products were obtained in most cases. No co-catalyst or activator is required, and water is the only by-product in the reactions. Heterogeneous nature of the catalyst made it reusable for further chemical reactions
Keywords:
Amine, propargylamine, three-component reactions, ZnO
Affiliation:
Department of Chemistry, Faculty of Science, Shiraz University, Shiraz 71454,I. R. Iran