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Combinatorial Chemistry & High Throughput Screening
ISSN (Print): 1386-2073
ISSN (Online): 1875-5402
Epub Full Text Article
DOI: 10.2174/1386207316666131217100416      Price:  $95

Computational Evidence for the Reactivation Process of Human Acetylcholinesterase Inhibited by Carbamates

Author(s): Karina Silvia Matos, Elaine F. F. da Cunha, Ruben Abagyan and Teodorico C. Ramalho
Acetylcholinesterase (AChE) is responsible for hydrolysis of acetylcholine (ACh), a function, which if disrupted, leads to cholinergic syndrome. Carbamates (CB) and organophosphorus compounds (OP) are AChE inhibitors, toxic and capable of causing severe poisoning or death to exposed individuals. The AChE reactivation is considered the main function of the oximes. In case of poisoning by CB, there is no consistent data in the literature for an oxime reactivation mechanism. In this work, we evaluated the affinity and reactivity of oximes with activity already reported against AChE inhibited by the OP chemical warfare agent ciclosarin, with MmAChE and HsAChE active sites inhibited by the CB pesticide carbofuran. Thus, our theoretical data indicate that HLO-7, BI-6 and K005 compounds may be promising reactivators of AChE inhibited by carbofuran
Acetylcholinesterase, Docking studies, Neurotoxic agents, Oximes, theoretical calculation
Chemistry Department, Federal University of Lavras, Campus Universitário, 3037, 37200-000, Lavras, MG, Brazil