Current Immunology Reviews

Cecil Czerkinsky  
Institut de Pharmacologie Moleculaire et Cellulaire
UMR 7275 CNRS-INSERM-UNISA
660 Route des Lucioles
Valbonne, 06560
France

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Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections

Author(s): Kathryn E. McGovern and Emma H. Wilson

Affiliation: School of Medicine, Division of Biomedical Sciences, University of California, Riverside, CA, 92521- 0129, USA.

Keywords: CCL21, CCR7, cell trafficking, chemokine, parasite, Toxoplasma.

Abstract:

Parasites are diverse eukaryotic pathogens that can have complex life cycles. Their clearance, or control within a mammalian host requires the coordinated effort of the immune system. The cell types recruited to areas of infection can combat the disease, promote parasite replication and survival, or contribute to disease pathology. Location and timing of cell recruitment can be crucial. In this review, we explore the role chemokines play in orchestrating and balancing the immune response to achieve optimal control of parasite replication without promoting pathology.

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Article Details

VOLUME: 9
ISSUE: 3
Page: [157 - 168]
Pages: 12
DOI: 10.2174/1573395509666131217000000