Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections
Kathryn E. McGovern and Emma H. Wilson
Affiliation: School of Medicine, Division of Biomedical Sciences, University of California, Riverside, CA, 92521- 0129, USA.
Keywords: CCL21, CCR7, cell trafficking, chemokine, parasite, Toxoplasma.
Parasites are diverse eukaryotic pathogens that can have complex life cycles. Their clearance, or control within
a mammalian host requires the coordinated effort of the immune system. The cell types recruited to areas of infection can
combat the disease, promote parasite replication and survival, or contribute to disease pathology. Location and timing of
cell recruitment can be crucial. In this review, we explore the role chemokines play in orchestrating and balancing the
immune response to achieve optimal control of parasite replication without promoting pathology.
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