Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections

Author(s): Kathryn E. McGovern, Emma H. Wilson.

Journal Name:Current Immunology Reviews

Volume 9 , Issue 3 , 2013

Abstract:

Parasites are diverse eukaryotic pathogens that can have complex life cycles. Their clearance, or control within a mammalian host requires the coordinated effort of the immune system. The cell types recruited to areas of infection can combat the disease, promote parasite replication and survival, or contribute to disease pathology. Location and timing of cell recruitment can be crucial. In this review, we explore the role chemokines play in orchestrating and balancing the immune response to achieve optimal control of parasite replication without promoting pathology.

Keywords: CCL21, CCR7, cell trafficking, chemokine, parasite, Toxoplasma.

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2013
Page: [157 - 168]
Pages: 12
DOI: 10.2174/1573395509666131217000000
Price: $58