Experimental Fracture Protocols in Assessments of Potential Agents for Osteoporotic Fracture Healing Using Rodent Models

Author(s): Nurul ‘Izzah Ibrahim, Sharlina Mohamad, Norazlina Mohamed, Ahmad Nazrun Shuid.

Journal Name: Current Drug Targets

Volume 14 , Issue 14 , 2013

Abstract:

Osteoporosis may cause bone fracture even under slight trauma. Osteoporotic fracture has become a major public health problem but until today, the treatments available are not satisfactory. Many pre-clinical testings on animals were done to find new agents that can be sourced from natural products and synthetic drugs for osteoporotic fracture healing. Animal models are more appropriate for fracture healing study than human subject due to several reasons including the ethical issues involved. The bones of rodents are similar to human in term of their morphological change and response to therapy. Small rodents such as rats and mice are suitable animal models for fracture healing studies as they have a similar bone remodeling system to human. To date, there is no specific guideline to carry out fracture healing studies in animal models for the evaluation of new agents. This paper highlights the protocols of various fracture and fixation methods for experimental osteoporotic fracture healing using rodent models.

Keywords: Bone fracture, fracture fixation, fracture healing, fracture method, osteoporosis, rodents.

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Article Details

VOLUME: 14
ISSUE: 14
Year: 2013
Page: [1642 - 1650]
Pages: 9
DOI: 10.2174/1389450114666131216224003
Price: $58

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