Osteoporosis may cause bone fracture even under slight trauma. Osteoporotic fracture has become a major public
health problem but until today, the treatments available are not satisfactory. Many pre-clinical testings on animals were
done to find new agents that can be sourced from natural products and synthetic drugs for osteoporotic fracture healing.
Animal models are more appropriate for fracture healing study than human subject due to several reasons including the
ethical issues involved. The bones of rodents are similar to human in term of their morphological change and response to
therapy. Small rodents such as rats and mice are suitable animal models for fracture healing studies as they have a similar
bone remodeling system to human. To date, there is no specific guideline to carry out fracture healing studies in animal
models for the evaluation of new agents. This paper highlights the protocols of various fracture and fixation methods for
experimental osteoporotic fracture healing using rodent models.
Keywords: Bone fracture, fracture fixation, fracture healing, fracture method, osteoporosis, rodents.
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