Phenanthroindolizidine alkaloids are a well-known class of compounds due to their interesting biological activities,
especially anticancer ones. Represented by more than 60 substances, they are mainly isolated from plants of the
Moraceae and Asclepiadaceae families. In the last 30 years, a great effort has been made aiming the synthesis of these
compounds and analogues to be applied in medicinal chemistry.
Keywords: Alkaloids, antofine, anticancer, anti-inflammatory, antifungal, antibacterial, biaryl coupling, indolizidines, phenanthroindolizidines,
total synthesis, typlophorine, tylocrebrine.
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