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Recent Patents on Cardiovascular Drug Discovery
ISSN (Print): 1574-8901
ISSN (Online): 2212-3962
Epub Abstract Ahead of Print
DOI: 10.2174/1574890108666131213100613      Price:  $140









Canagliflozin : a New Hope in the Antidiabetic Armamentarium

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Author(s): Vasiliki K Katsi, Christos A Michalakeas, Charalambos E Grassos, Georgia D. Vamvakou, John P. Lekakis, Dimitris Tousoulis, Christodoulos I Stefanadis, Thomas K Makris and Ioannis E Kallikazaros
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Abstract:
Canagliflozin-with the patent number WO2011142478A1- belongs to a novel class of antidiabetic drugs known as SGLT2 inhibitors, which has been approved by FDA in March 2013. This medication acts through the inhibition of glucose reabsorption in the kidney resulting in glucosuria and thus lowering of glucose blood levels. There are several phase III clinical ongoing trials involving this new class of medications. So far promising results have been shown. This review article summarizes current knowledge regarding the novel SGLT2 inhibitor canagliflozin and its future perspectives in the treatment of type 2 diabetes mellitus
Affiliation:
Cardiology Department, Hippocratio Hospital, Greece. Vas. Sofias Avenue 114, Post code: 11527, Athens, Greece