Engineering Three-Dimensional Cardiac Microtissues for Potential Drug Screening Applications
L. Wang, G. Huang, B. Sha, S. Wang, Y.L. Han, J. Wu, Y. Li, Y. Du, T.J. Lu and F. Xu
Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China 710049.
Heart disease is one of the major global health issues. Despite rapid advances in cardiac tissue engineering, limited
successful strategies have been achieved to cure cardiovascular diseases. This situation is mainly due to poor understanding
of the mechanism of diverse heart diseases and unavailability of effective in vitro heart tissue models for cardiovascular
drug screening. With the development of microengineering technologies, three-dimensional (3D) cardiac microtissue
(CMT) models, mimicking 3D architectural microenvironment of native heart tissues, have been developed. The
engineered 3D CMT models hold greater potential to be used for assessing effective drugs candidates than traditional twodimensional
cardiomyocyte culture models. This review discusses the development of 3D CMT models and highlights
their potential applications for high-throughput screening of cardiovascular drug candidates.
Keywords: Bioprinting, cardiac microtissues, cell encapsulation, cell microenvironment, drug screening, high throughput, hydrogels,
stem cells, three dimensional, tissue engineering.
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