Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard


Polymeric Systems as Nanodevices for siRNA Delivery

Author(s): Marcio J. Tiera, Qin Shi, Hellen Franciane Gonçalves Barbosa, Julio C. Fernandes.


The delivery of small interfering RNAs (siRNAs) is a promising approach to silencing gene expression aimed at treating infections, cancer, neurodegenerative diseases and various other disorders. Recent progress in this area has been achieved with nanodevices possessing multiple properties and assembled with new, biodegradable, synthetic polymers and polysaccharides. Different synthetic routes and multiple strategies, such as multilayer systems and stimuliresponsive polymers, have been developed to attain high efficiencies. This review covers the most important, promising and successful approaches to improve siRNA delivery. It is a concise report on multiple strategies employed, including cell-specific delivery coupling ligands or antibodies with nanodevices to improve siRNA efficiency and specificity.

Keywords: Gene therapy, nanoparticles, multifunctional, polycations, stimuli-responsive polymers, siRNA delivery.

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Article Details

Year: 2013
Page: [358 - 369]
Pages: 12
DOI: 10.2174/156652321305131212125042
Price: $58