Organocatalytic Asymmetric Aldol Reactions in Aqueous or Neat Conditions: Review of Data Published in 2009-2013
Mihaly Bartok and Gyorgy Dombi
Affiliation: MTA-SZTE Stereochemistry Research Group, Dom ter 8, H-6720 Szeged, Hungary.
Keywords: Acids, aldol reaction, amino acids, asymmetric reaction, carboxamides, diamines, hydroxyamino acid, organocatalysts,
peptides, peptide-based alcohols.
The aim of this review was to collect the results published in 2009-2013 on asymmetric aldol reactions taking
place in aqueous media (water, brine) and in the absence of solvents (neat), to highlight the catalysts identified as best,
and, in the course of doing so, to present the trends of research in this field. The five groups of organocatalysts discussed
are: 1. Amino acids and esterified hydroxyamino acids; 2. Carboxamides of amino acids; 3. Peptides and derivatives; 4.
Peptide-based alcohols; 5. 1, 2-Diamines and derivatives. The efficiency of the catalysts is characterized by their concentration
in the reaction, reaction time, their selectivity (anti/syn) and their enantioselectivity.
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