Green tea is one of the most popular beverages around the world. For several decades, numerous epidemiological, preclinical
and clinical studies have demonstrated that green tea polyphenols (GTPs), especially epigallocatechin-3-gallate (EGCG) have
cancer-preventing effects on various cancers. In this review, we present inhibition of carcinogenesis in different animal models by GTPs
or EGCG, including prostate cancer, bladder cancer, breast cancer, intestinal cancer, colon cancer, gastric cancer, lung cancer, oral cancer
and skin cancer. In vitro studies showed that GTPs/EGCG potently induces apoptosis, cell cycle arrest and suppresses metastasis in tumor
cells but not in their normal cell counterparts. The molecular mechanisms of these activities are discussed in detail to elucidate
GTPs/EGCG downstream carcinogenesis signaling pathways and their values of perspective of chemoprevention and treatment for
Cancer, chemoprevention, green tea, polyphenols, treatment.
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.