Sepsis is the complex syndrome characterized by an imbalance between proinflammatory and antiinflammatory
response to infection. The brain may be affected during the sepsis, and acute and long-term brain
dysfunctions have been observed in both animal models and septic patients. Oxidative stress and antioxidant systems may
prove the basis underling brain dysfunction in sepsis. The antioxidant therapy may be theoretically achieved by the
following strategies: restoring endogenous antioxidants and nutrients and supplementation with exogenous trace elements,
vitamins, and nutrients with antioxidant proprieties; or administering drugs that reduce oxidative stress, such as NAcetylcysteine
(NAC), vitamins and statins. In the review, we described below the involvement of oxidative stress and
antioxidants defenses and potential utility of these strategies and present data regarding their use in sepsis.
Keywords: Antioxidants, Mitochondrial dysfunction, NAC, Oxidative stress, Statins, Vitamins.
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