Green Synthesis of Novel Phthalimide Derivatives of Aspirin and P-aminosalicylic Acid as Potential Analgesic- antipyretic and Anti-tuberculosis Agents

Author(s): Yervala D. Reddy , Chittireddy V.R. Reddy , Pramod K. Dubey .

Journal Name: Letters in Organic Chemistry

Volume 11 , Issue 4 , 2014

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Abstract:

Green synthesis of novel compounds 4-(2-carboxybenzamido)-2-hydroxybenzoic acids 3a-3e, 4-(1, 3- dioxoisoindolin-2-yl)-2-hydroxybenzoic acids 4a-4e, 2-acetoxy-4-(2-carboxybenzoylamino)benzoic acids 6a-6e and 2- acetoxy-4-(1, 3-dioxo-1, 3-dihydroisoindol-2-yl)-benzoic acids 8a-8e has been developed which were analogs of aspirin (used as analgesic, anti-pyretic and cardiovascular drug) and para-aminosalicylic acid ( used as anti-tuberculosis agent).

Keywords: Phthalic anhydrides, p-aminosalicylic acid, analgesic, antipyretic & anti-tuberculosis agents.

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Article Details

VOLUME: 11
ISSUE: 4
Year: 2014
Page: [303 - 312]
Pages: 10
DOI: 10.2174/1570178610666131210234152
Price: $58

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