Current Genomics

Christian Néri
Institute of Biology Paris-Seine
CNRS UMR 8256 and UPMC
Paris, 75005


Pharmacogenetics of Parkinson’s Disease – Through Mechanisms of Drug Actions

Author(s): Marek Drozdzik, Monika Bialecka and Mateusz Kurzawski

Affiliation: Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp. 72 70-111 Szczecin, Poland.

Keywords: Parkinson's disease, Pharmacogenetics, Genetic polymorphism.


In the last years due to development of molecular methods a substantial progress in understanding of genetic associations with drug effects in many clinical disciplines has been observed. The efforts to define the role of genetic polymorphisms in optimizing pharmacotherapy of Parkinson’s disease (PD) were also undertaken. So far, some promising genetic loci for PD treatment were determined. In the review pharmacogenetic aspects of levodopa, dopamine agonists and COMT inhibitors are discussed.

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Article Details

Page: [568 - 577]
Pages: 10
DOI: 10.2174/1389202914666131210212521