Parkinson's Disease: From Genetics to Clinical Practice

Author(s): Jordi Clarimon, Jaime Kulisevsky.

Journal Name: Current Genomics

Volume 14 , Issue 8 , 2013

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Abstract:

Breakthroughs in genetics over the last decade have radically advanced our understanding of the etiological basis of Parkinson's disease (PD). Although much research remains to be done, the main genetic causes of this neurodegenerative disorder are now partially unraveled, allowing us to feel more confident that our knowledge about the genetic architecture of PD will continue to increase exponentially. How and when these discoveries will be introduced into general clinical practice, however, remains uncertain. In this review, we provide a general summary of the progress in the genetics of PD and discuss how this knowledge will contribute to the diagnosis and clinical management of patients with, or at risk of this disorder.

Keywords: Genetics, Parkinson's disease, Mendelian genes, Genetic testing, PARK, Clinical genetics, Genetic risk factor.

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Article Details

VOLUME: 14
ISSUE: 8
Year: 2013
Page: [560 - 567]
Pages: 8
DOI: 10.2174/1389202914666131210212305
Price: $58

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