Current Genomics

Christian Néri
Institute of Biology Paris-Seine
CNRS UMR 8256 and UPMC
Paris, 75005
France

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Parkinson's Disease: From Genetics to Clinical Practice

Author(s): Jordi Clarimon and Jaime Kulisevsky

Affiliation: Genetics of Neurodegenerative Disorders Unit, IIB-Sant Pau, Neurology Department, Hospital de la Santa Creu i Sant Pau. Sant Antoni M. Claret 167, 08025 Barcelona, Spain.

Keywords: Genetics, Parkinson's disease, Mendelian genes, Genetic testing, PARK, Clinical genetics, Genetic risk factor.

Abstract:

Breakthroughs in genetics over the last decade have radically advanced our understanding of the etiological basis of Parkinson's disease (PD). Although much research remains to be done, the main genetic causes of this neurodegenerative disorder are now partially unraveled, allowing us to feel more confident that our knowledge about the genetic architecture of PD will continue to increase exponentially. How and when these discoveries will be introduced into general clinical practice, however, remains uncertain. In this review, we provide a general summary of the progress in the genetics of PD and discuss how this knowledge will contribute to the diagnosis and clinical management of patients with, or at risk of this disorder.

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Article Details

VOLUME: 14
ISSUE: 8
Page: [560 - 567]
Pages: 8
DOI: 10.2174/1389202914666131210212305