The Mechanism by which the Phenothiazine Thioridazine Contributes to Cure Problematic Drug-Resistant Forms of Pulmonary Tuberculosis: Recent Patents for “New Use”
Leonard Amaral, Ana Martins, Gabriella Spengler, Attila Hunyadi and Joseph Molnar
Affiliation: Travel Medicine, Centro de Malária Doenças Tropicais, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Rua Junqueira 100, 1349-008 Lisbon, Portugal.
At this moment, over half million patients suffer from multi-drug resistant tuberculosis (MDR-TB) according
to the data from the WHO. A large majority is terminally ill with essentially incurable pulmonary tuberculosis. This
herein mini-review provides the experimental and observational evidence that a specific phenothiazine, thioridazine, will
contribute to cure any form of drug-resistant tuberculosis. This antipsychotic agent is no longer under patent protection for
its initial use. The reader is informed on the recent developments in patenting this compound for “new use” with a special
emphasis on the aspects of drug-resistance. Given that economic motivation can stimulate the use of this drug as an antitubercular
agent, future prospects are also discussed.
Keywords: Curing of XDR TB, mechanism of killing, Mycobacterium tuberculosis, thioridazine.
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