Letters in Drug Design & Discovery

Atta-ur-Rahman  , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: lddd@benthamscience.org

Back

A Facile Synthesis and Anticancer Activity Evaluation of Spiro Analogues of Benzothiazolylchromeno/pyrano Derivatives

Author(s): Anand Kumar Arya, Kulbhushan Rana and Mahendra Kumar

Affiliation: Department of Chemistry, University of Rajasthan, Jaipur-302 055, India.

Keywords: Multicomponent reactions, Spiroheterocycles, Cytotoxic activity, SRB assay, 2-aminobenzothiazole, Water.

Abstract:

The spiro analogues of benzothiazolylchromenopyranopyridine, benzothiazolyl- chromenoquinoline, benzothiazolylpyranoquinoline, benzothiazolylchromenopyridopyrimidine and benzothiazolylpyranopyridopyrimidine have been synthesized by an efficient domino reaction using sulfamic acid as catalyst in aqueous medium and screened for their cytotoxic activity against tumor cell lines, namely human cancer cell lines of colon (sw620), breast (MCF-7), cervix (HeLa) and heptatoma (HepG2) using a sulforhodamine B (SRB) assay. The synthesized compounds have shown promising cytotoxic activity against MCF-7 (breast cancer) & HeLa (cervical cancer) cancer cell lines.

Reprint ePrint Rights & PermissionsPrintExport

Article Details

VOLUME: 11
ISSUE: 5
Page: [594 - 600]
Pages: 7
DOI: 10.2174/1570180811666131210000903