Studies of the neuroprotective activity of a series of monoterpene-derived compounds on the MPTP mice
model showed that 4-[(3aR,7aS)-1,3,3a,4,5,7a-hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol 15 possessed
a considerable neuroprotective activity. Compound 15 was synthesized by one-stage reaction of (+)-2-carene with
vanillin. It has low acute toxicity and significantly decreased the development of catalepsy evoked by haloperidol in rats.
Keywords: Neuroprotection, Parkinson disease, MPTP, Mice, Monoterpene, Carene, Vanillin.
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