Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model

Author(s): Alla V. Pavlova , Irina V. Il'ina , Ekaterina A. Morozova , Dina V. Korchagina , Svetlana Yu. Kurbakova , Irina V. Sorokina , Tatyana G. Tolstikova , Konstantin P. Volcho , Nariman F. Salakhutdinov .

Journal Name: Letters in Drug Design & Discovery

Volume 11 , Issue 5 , 2014

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Studies of the neuroprotective activity of a series of monoterpene-derived compounds on the MPTP mice model showed that 4-[(3aR,7aS)-1,3,3a,4,5,7a-hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol 15 possessed a considerable neuroprotective activity. Compound 15 was synthesized by one-stage reaction of (+)-2-carene with vanillin. It has low acute toxicity and significantly decreased the development of catalepsy evoked by haloperidol in rats.

Keywords: Neuroprotection, Parkinson disease, MPTP, Mice, Monoterpene, Carene, Vanillin.

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Article Details

Year: 2014
Page: [611 - 617]
Pages: 7
DOI: 10.2174/1570180811666131210000316
Price: $58

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