Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model
Alla V. Pavlova, Irina V. Il'ina, Ekaterina A. Morozova, Dina V. Korchagina, Svetlana Yu. Kurbakova, Irina V. Sorokina, Tatyana G. Tolstikova, Konstantin P. Volcho and Nariman F. Salakhutdinov
Affiliation: N.N.Vorozhtsov Novosibirsk Institute of Organic Chemistry, Lavrentiev av., 9, 630090 Novosibirsk, Russian Federation.
Keywords: Neuroprotection, Parkinson disease, MPTP, Mice, Monoterpene, Carene, Vanillin.
Studies of the neuroprotective activity of a series of monoterpene-derived compounds on the MPTP mice
model showed that 4-[(3aR,7aS)-1,3,3a,4,5,7a-hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol 15 possessed
a considerable neuroprotective activity. Compound 15 was synthesized by one-stage reaction of (+)-2-carene with
vanillin. It has low acute toxicity and significantly decreased the development of catalepsy evoked by haloperidol in rats.
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