Synthesis and Pharmacological Evaluation of Novel 3-Substituted Indole Derivatives as Potential Anti-Inflammatory and Analgesic Agents
Mayura A. Kale, Ashok S. Narute and Tukaram M. Kalyankar
Facile synthesis of some novel anti-inflammatory and analgesic agents was established by initially treating 3-acetyl indole (1) with the various aromatic aldehydes (2) which afforded the corresponding 3-chalconylindoles 3a-e. These products 3a-e upon treatment with hydrazine hydrate gave the resultant pyrazoline derivatives 4a-e. Also, the diazotized salt of aniline, when reacted with these pyrazoline indoles 4a-e yielded azo derivatives of pyrazoline indoles 5a-e. These newly synthesized compounds were screened for the mentioned activities and were found to possess good potential to act against inflammation and pain.
Indole, pyrazoline, azo derivatives, anti-inflammatory, analgesic & indomethacin
Government College of Pharmacy, opposite Government Polytechnic, Railway station road, Osmanpura, Aurangabad (M.S), India.