Synthesis and Pharmacological Studies of Novel 3-Substituted Indole Derivatives as Potential Anti-Inflammatory and Analgesic Agents
Mayura A. Kale, Ashok S. Narute and Tukaram M. Kalyankar
Affiliation: Government College of Pharmacy, opposite Government Polytechnic, Railway station road, Osmanpura, Aurangabad (M.S), India - 431 005.
Facile synthesis of some novel anti-inflammatory and analgesic agents was established by initially treating 3-
acetyl indole (1) with the various aromatic aldehydes (2) which afforded the corresponding 3-chalconylindoles 3a-e.
These products 3a-e upon treatment with hydrazine hydrate gave the resultant pyrazoline derivatives 4a-e. Also, the diazotized
salt of aniline, when reacted with these pyrazoline indoles 4a-e yielded azo derivatives of pyrazoline indoles 5a-e.
These newly synthesized compounds were screened for the mentioned activities and were found to possess good potential
to act against inflammation and pain.
Keywords: Analgesic & indomethacin, anti-inflammatory, azo derivatives, indole, pyrazoline.
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