The aim of this research was to formulate the ofloxacin loaded lipospheres as a drug delivery system to improve
the oral bioavailability, reduce toxicity and achieve better patient compliance. The ofloxacin loaded lipospheres
were formulated by melt dispersion technique using cetyl alcohol; poly vinyl alcohol (0.1%w/v) and pectin (1%w/v) act as
lipid carrier, surfactant and co-surfactant respectively. The in vitro release kinetic studies were carried out for lipospheres
loaded with ofloxacin and the value of R2 in Higuchi model is greater than 0.99 and release exponent (n), was found to be
more than 0.5 that is Non-Fickian type. The in vitro release kinetic followed dissolution and then Korsmeyer–Peppas
models. The bioavailability of ofloxacin loaded lipospheres was performed in rabbits after oral administration was studied.
The plasma drug concentration was estimated by using a simple, accurate and precise high performance thin layer
chromatographic technique. The pharmacokinetics studies demonstrated that the liposphere system enhance the bioavailability
of ofloxacin by 2.45 fold after oral administration. Based on these results, we concluded that lipospheres might be a
promising lipid based colloidal carrier system to enhance the bioavailability of ofloxacin.
Keywords: Bioavailability, lipospheres, lipids, melt dispersion, ofloxacin, release kinetics, surfactants.
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