Novel poly-L-lactic acid (PLLA) microtube array membranes (MTAMs) with a porous wall structure were prepared by electrospinning.
Porogen of polyethylene glycol (PEG) was mixed with PLLA and dissolved in a dichloromethane/dimethylformamide solvent.
The solution dope was delivered to the outer layer of coaxial spinneret, while the PEG/polyethylene oxide (50/50 wt. %) aqueous
solution was delivered to the core layer, to form arrays of core-shell fibers through an electrospinning process. Porogen was then washed
off to produce array of microtubes with a porous wall structure. The morphology and physical properties of the MTAMs were characterized
by scanning electron microscopy (SEM), a texture analyzer (TA), and a thermogravimetric analysis (TGA). With porogen content of
0~50 wt.%, pores, ranging from a few tens of nanometers to a few microns, were clearly seen in SEM micrographs for the surface of
PLLA/PEG0-50 MTAMs after the washing process. However, porogen was effectively washed off only from PLLA/PEG30-50 MTAMs, thus
their wall structure was transformed from a dense to porous one. PLLA/PEG MTAMs remained relatively hydrophobic. Young’s modulus
of PLLA/PEG MTAMs decreased from 850 to 400 kPa, while the fracture work increased from 854 g
Electrospinning, microtube array membrane, MTAM, permeation, poly-L-lactic acid (PLLA), porogen
Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei 11052, Taiwan