Potential Effects of Cannabidiol as a Wake-Promoting Agent
Eric Murillo-Rodriguez, Andrea Sarro-Ramirez, Daniel Sanchez, Stephanie Mijangos-Moreno, Alma Tejeda-Padron, Alwin Poot-Ake, Khalil Guzman, Elda Pacheco-Pantoja and Oscar Arias-Carrion
Affiliation: Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, Division Ciencias de la Salud, Universidad Anahuac Mayab, Carretera Merida-Progreso Km, 15.5, A.P. 96 Cordemex C.P. 97310, Merida, Yucatan, Mexico.
Over the last decades, the scientific interest in chemistry and pharmacology of cannabinoids has increased.
Most attention has focused on Δ9-tetrahydrocannabinol (Δ9-THC) as it is the psychoactive constituent of Cannabis sativa
(C. sativa). However, in previous years, the focus of interest in the second plant constituent with non-psychotropic
properties, cannabidiol (CBD) has been enhanced. Recently, several groups have investigated the pharmacological
properties of CBD with significant findings; furthermore, this compound has raised promising pharmacological properties
as a wake-inducing drug. In the current review, we will provide experimental evidence regarding the potential role of
CBD as a wake-inducing drug.
Keywords: Dopamine, hypothalamus, marijuana, sleep, sleepiness.
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