Potential Effects of Cannabidiol as a Wake-Promoting Agent
Eric Murillo-Rodriguez, Andrea Sarro-Ramirez, Daniel Sanchez, Stephanie Mijangos-Moreno, Alma Tejeda-Padron, Alwin Poot-Ake, Khalil Guzman, Elda Pacheco-Pantoja and Oscar Arias-Carrion
Affiliation: Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, Division Ciencias de la Salud, Universidad Anahuac Mayab, Carretera Merida-Progreso Km, 15.5, A.P. 96 Cordemex C.P. 97310, Merida, Yucatan, Mexico.
Keywords: Dopamine, hypothalamus, marijuana, sleep, sleepiness.
Over the last decades, the scientific interest in chemistry and pharmacology of cannabinoids has increased.
Most attention has focused on Δ9-tetrahydrocannabinol (Δ9-THC) as it is the psychoactive constituent of Cannabis sativa
(C. sativa). However, in previous years, the focus of interest in the second plant constituent with non-psychotropic
properties, cannabidiol (CBD) has been enhanced. Recently, several groups have investigated the pharmacological
properties of CBD with significant findings; furthermore, this compound has raised promising pharmacological properties
as a wake-inducing drug. In the current review, we will provide experimental evidence regarding the potential role of
CBD as a wake-inducing drug.
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