Behavior of EDTMP (Ethylene-diaminetetramethylene-phosphonate)- Nanoparticles in Blood: Considerations on the Site of Injection
Beatriz Ferreira de Carvalho Patricio, Osmar Flavio da Silveira Leite Neto, Marta de Souza Albernaz and Ralph Santos-Oliveira
Affiliation: Nuclear Engineering Institute, Rua Helio de Almeida 75 – Rio de Janeiro – Brazil.
Keywords: Animal model, biodistribution, cancer, nanotechnology, oncology.
The nanotechnology and the use of nanoparticles are increasing each day. The number of experiments with
nanoparticles is enormous and is corroborating the use in humans. However some points must be more defined before a
final approval. In this study we analyzed nanoparticles of EDTMP under different conditions in rats and observed some
characteristics that should be taken into account. Nanoparticles were injected either intraocular or in a jugular vein, and
the data were compared. The behaviors of the samples were very different, which may have led to erroneous interpretation
of nanoparticle data in previous studies by many authors. In all cases, the results of the biodistribution were quite different,
which may lead to different conclusions. Analyzing the data, we conclude that the biodistribution test should be standardized,
and the way that it is conducted may change the final results drastically.
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