Do You See What I See: Recognition of Protozoan Parasites by Toll-Like Receptors
Debopam Ghosh and Jason S. Stumhofer
Affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W. Markham St., Slot 511, Little Rock, AR 72205, USA.
Keywords: Glycophosphatidylinositol, innate immune response, MyD88, parasite, protozoan, Toll-like receptor.
Toll-like receptors (TLRs) are important for recognizing a variety of pathogens, including protozoan parasites,
and initiating innate immune responses against them. TLRs are localized on the cell surface as well as in the endosome,
and are implicated in innate sensing of these parasites. In this review, we will discuss recent findings on the identification
of parasite-derived pathogen associated molecular patterns and the TLRs that bind them. The role of these TLRs in
initiating the immune response against protozoan parasitic infections in vivo will be presented in the context of murine
models of infection utilizing TLR-deficient mice. Additionally, we will explore evidence that TLRs and genetic variants
of TLRs may impact the outcome of these parasitic infections in humans.
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