Myocardial Ischemia/Reperfusion Injury: Potential of TRPV1 Agonists as Cardioprotective Agents
George S. Abela,
Donna H. Wang.
Myocardial Ischemia/Reperfusion (I/R) induced injury has widespread detrimental effects partially negating the
benefits obtained from early revascularization in Acute Myocardial Infarction. Various complex mechanisms contribute to
I/R injury and different agents targeting those specific mechanisms are being studied. Despite continued research and
widespread interest, none of them have become incorporated into everyday practice. The TRPV1 (transient receptor
potential vanilloid 1) channel is a non selective cation channel predominantly expressed in sensory neurons with the nerve
fibers innervating the heart and blood vessels. Multiple studies have demonstrated the importance of the activation of
TRPV1 and subsequent release of sensory neurotransmitters in cardioprotection. This review focuses on the role of
TRPV1 in prevention of cardiac I/R injury, the work that has been done so far and future implications for TRPV1 agonists
as cardioprotective agents.
Keywords: Agonist, cardioprotection, Ischemia/Reperfusion, myocardium, TRPV1.
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