The efficacy of herbal medicine has been confirmed in treatment of diabetes mellitus (DM) by amelioration of
oxidative stress. The present study was designed to investigate protective effects of Cichorium intybus extract (CIE)
against oxidative damage in diabetic rats. In this study, the rats were divided into the control (C), diabetic (D), D + CIE–
treated (125 mg/kg/day) groups. Male Sprague–Dawley rats aged 9 weeks (160 ± 15 g) were administered with
streptozotocin (STZ, 60 mg/kg) intraperitoneally (ip) to induce experimental diabetes. From 3 days after STZ
administration to the end of the study (4 weeks) the ethanolic extract of CIE was administered (i.p) to diabetic rats. Body
weight and blood glucose were measured weekly. At the end of the 4-week period, blood was drawn for biochemical
assay, in order to determine the changes of cellular antioxidant defense system, serum oxidative damage and serum lipid
were measured profile. CIE injection to diabetic rats resulted in significant reduction in blood glucose, triglyceride (TG),
total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) levels and significant elevation high density
lipoprotein cholesterol (HDL-C) level as well as increase in the body weight as compared with the rats treated with STZ
alone. In the treated diabetic group, we also observed the significant increase in reduced glutathione (GSH), superoxide
dismutase (SOD), glutathione-S-transferase (GST) and catalase (CAT) with decline in malondialdehyde (MDA) level
compared with the non-treated diabetic group. These results suggest that the Cichorium intybus extract has antioxidant
properties and prevents diabetes complications by modulation of oxidative stress system.
Cichorium Intybus, diabetic rats, oxidative stress, streptozotocin.
Department of Basic Medical Sciences, Neyshabur University of Medical of Sciences, Neyshabur, Iran.