Serelaxin: New Investigational Treatment in Acute Heart Failure
Sarmad Said and Debabrata Mukherjee
Affiliation: Department of Internal Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, 4800 Alberta Avenue, El Paso, Texas, USA 79905.
Keywords: Acute heart failure, cardiac failure, cardiovascular diseases, cognitive impairment, dyspnea, hospitalized patients,
ischemic cardiomyopathy, non-ischemic cardiomyopathy, relaxin, serelaxin, vasodilator.
Over the last decade several pharmacological approaches for acute heart failure have been introduced, however,
no drastic change in the medical management apart from device-dependent therapy was observed. Essentially vasodilators
and diuretics as primary therapy in acute heart failure was discussed and encouraged in the guidelines but no breakthrough
in the treatment of acute heart failure was achieved. More recently, clinical trials of relaxin and its recombinant form, i.e.,
serelaxin in patients with acute heart failure demonstrated a significant clinical improvement with favorable safety and
tolerability profile in symptomatic heart failure patients. This report reviews the potential beneficial effects and role of
serelaxin in the setting of acute heart failure.
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