Complex Inheritance for Susceptibility to Sudden Cardiac Death

Author(s): Raha Pazoki, Michael W.T. Tanck, Arthur A.M. Wilde, Connie R. Bezzina.

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 39 , 2013

Become EABM
Become Reviewer

Abstract:

Sudden cardiac death (SCD) from ventricular fibrillation during myocardial infarction is a leading cause of total and cardiovascular mortality. It has a multifactorial, complex nature and aggregates in families, implicating the involvement of heritable factors in the determination of risk. During the last few years, genome-wide association studies have uncovered common genetic variants modulating risk of SCD. We here review the current insight on genetic determinants of SCD in the community and describe the genome-wide association approaches undertaken thus far in uncovering genetic determinants of SCD risk.

Keywords: Ventricular arrhythmia, genome-wide association studies, sudden cardiac death, genetics.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 19
ISSUE: 39
Year: 2013
Page: [6864 - 6872]
Pages: 9
DOI: 10.2174/138161281939131127112906
Price: $58

Article Metrics

PDF: 9