Abstract
Fatty acids have an important role in providing energy for sustained contractile activity and viability of the heart. However, considerable evidence now supports a role for fatty acids in the modulation of cardiovascular pathology as well. This may be beneficial or detrimental due to the structural differences in the various fatty acids. Polyunsaturated fatty acids appear to provide important protection to the heart during ischemic reperfusion challenge. Conversely, trans fatty acids are thought to mediate detrimental cardiac effects. Potentially pathological features of ischemic cardiomyocytes may be manifested as qualitative findings in studies of myocardial infarction and atherosclerosis. These general conclusions, however, are complicated by opposing effects that different fatty acids have even within the same group (i.e. n-6 versus n-3 fatty acids within the polyunsaturated fatty acids group, and industrial versus ruminant trans fats). Understanding more about how these fatty acid species alter ischemic myocardial injury is an increasingly attractive area of research. The identification of further targets of fatty acid interactions has great potential to provide valuable information for the modulation of cardiovascular disease.
Keywords: Ischemia, fatty acid, apoptosis, heart disease; reperfusion; atherosclerosis; trans fat, omega-3 fatty acid, polyunsaturated fatty acid.
Current Pharmaceutical Design
Title:Differential Effects of Trans and Polyunsaturated Fatty Acids on Ischemia/ Reperfusion Injury and its Associated Cardiovascular Disease States
Volume: 19 Issue: 39
Author(s): Riya Ganguly, Matthew S. Lytwyn and Grant N. Pierce
Affiliation:
Keywords: Ischemia, fatty acid, apoptosis, heart disease; reperfusion; atherosclerosis; trans fat, omega-3 fatty acid, polyunsaturated fatty acid.
Abstract: Fatty acids have an important role in providing energy for sustained contractile activity and viability of the heart. However, considerable evidence now supports a role for fatty acids in the modulation of cardiovascular pathology as well. This may be beneficial or detrimental due to the structural differences in the various fatty acids. Polyunsaturated fatty acids appear to provide important protection to the heart during ischemic reperfusion challenge. Conversely, trans fatty acids are thought to mediate detrimental cardiac effects. Potentially pathological features of ischemic cardiomyocytes may be manifested as qualitative findings in studies of myocardial infarction and atherosclerosis. These general conclusions, however, are complicated by opposing effects that different fatty acids have even within the same group (i.e. n-6 versus n-3 fatty acids within the polyunsaturated fatty acids group, and industrial versus ruminant trans fats). Understanding more about how these fatty acid species alter ischemic myocardial injury is an increasingly attractive area of research. The identification of further targets of fatty acid interactions has great potential to provide valuable information for the modulation of cardiovascular disease.
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Cite this article as:
Ganguly Riya, Lytwyn S. Matthew and Pierce N. Grant, Differential Effects of Trans and Polyunsaturated Fatty Acids on Ischemia/ Reperfusion Injury and its Associated Cardiovascular Disease States, Current Pharmaceutical Design 2013; 19 (39) . https://dx.doi.org/10.2174/138161281939131127111018
DOI https://dx.doi.org/10.2174/138161281939131127111018 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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