Mitochondrial Dynamics: An Emerging Paradigm in Ischemia-Reperfusion Injury

Author(s): Lesley Calo, Yi Dong, Rita Kumar, Karin Przyklenk, Thomas H. Sanderson.

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 39 , 2013

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Abstract:

Cardiomyocytes and neurons are highly susceptible to ischemia-reperfusion injury; accordingly, considerable effort has been devoted to elucidating the cellular mechanisms responsible for ischemia-reperfusion-induced cell death and developing novel strategies to minimize ischemia-reperfusion injury. Maintenance of mitochondrial integrity is, without question, a critical determinant of cell fate. However, there is emerging evidence of a novel and intriguing extension to this paradigm: mitochondrial dynamics (that is, changes in mitochondrial morphology achieved by fission and fusion) may play an important but as-yet poorly understood role as a determinant of cell viability. Focusing on heart and brain, our aims in this review are to provide a synopsis of the molecular mechanisms of fission and fusion, summarize our current understanding of the complex relationships between mitochondrial dynamics and the pathogenesis of ischemia-reperfusion injury, and speculate on the possibility that targeted manipulation of mitochondrial dynamics may be exploited for the design of novel therapeutic strategies for cardio- and neuroprotection.

Keywords: Heart, brain, ischemia, infarction, reperfusion injury, mitochondrial fission, mitochondrial fusion, apoptosis.

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Article Details

VOLUME: 19
ISSUE: 39
Year: 2013
Page: [6848 - 6857]
Pages: 10
DOI: 10.2174/138161281939131127110701
Price: $58

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