Current Immunology Reviews

Cecil Czerkinsky  
Institut de Pharmacologie Moleculaire et Cellulaire
UMR 7275 CNRS-INSERM-UNISA
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Valbonne, 06560
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CD8+ T Cell Responses to Plasmodium and Intracellular Parasites

Author(s): Nicolas Villarino and Nathan W. Schmidt

Affiliation: Department of Microbiology, M409 Walters Life Sciences, 1414 W. Cumberland Ave., Knoxville, TN 37996, USA.

Keywords: CD8+ T cell, immunity, Leishmania, malaria, Plasmodium, protozoa, Toxoplasma, Trypanosoma.

Abstract:

Parasitic protozoa are major threats to human health affecting millions of people around the world. Control of these infections by the host immune system relies on a myriad of immunological mechanisms that includes both humoral and cellular immunity. CD8+ T cells contribute to the control of these parasitic infections in both animals and humans. Here, we will focus on the CD8+ T cell response against a subset of these protozoa: Plasmodium, Toxoplasma gondii, Leishmania and Trypanosoma cruzi, with an emphasis on experimental rodent systems. It is evident a complex interaction occurs between CD8+ T cells and the invading protozoa. A detailed understanding of how CD8+ T cells mediate protection should provide the basis for the development of effective vaccines that prevent and control infections by these parasites.

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Article Details

VOLUME: 9
ISSUE: 3
Page: [169 - 178]
Pages: 10
DOI: 10.2174/1573395509666131126232327