Current Immunology Reviews

Cecil Czerkinsky  
Institut de Pharmacologie Moleculaire et Cellulaire
UMR 7275 CNRS-INSERM-UNISA
660 Route des Lucioles
Valbonne, 06560
France

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Dysfunctional Adaptive Immunity During Parasitic Infections

Author(s): Ryan A. Zander and Noah S. Butler

Affiliation: Department of Microbiology and Immunology, BMSB 1035, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA.

Keywords: B cell, chronic infection, exhaustion, helminth, T cell, parasite, protozoan.

Abstract:

Parasite-driven dysfunctional adaptive immunity represents an emerging hypothesis to explain the chronic or persistent nature of parasitic infections, as well as the observation that repeated exposure to most parasitic organisms fails to engender sterilizing immunity. This review discusses recent examples from clinical studies and experimental models of parasitic infection that substantiate the role for immune dysfunction in the inefficient generation and maintenance of potent anti-parasitic immunity. Better understanding of the complex interplay between parasites, host adaptive immunity, and relevant negative regulatory circuits will inform efforts to enhance resistance to chronic parasitic infections through vaccination or immunotherapy.

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Article Details

VOLUME: 9
ISSUE: 3
Page: [179 - 189]
Pages: 11
DOI: 10.2174/1573395509666131126230832