Momordica charantia and Type 2 Diabetes: From in vitro to Human Studies
Sandra D. Habicht, Christine Ludwig, Ray-yu Yang and Michael B. Krawinkel
Affiliation: Justus Liebig University, International Nutrition, Wilhelmstrasse 20, 35392 Giessen, Germany.
Keywords: Bitter gourd, bioactive compounds, diabetes, insulin resistance, momordica charantia, phytomedicine.
Type 2 diabetes is a growing health problem worldwide that is particularly severe in India and China. In these
areas, bitter gourd (Momordica charantia) is a popular vegetable which is traditionally known to have health beneficial
effects not only, but mainly, on diabetes. Bitter gourd could be a cheap possibility to help the poor in these and other
countries to control their blood glucose levels. This review describes anti-diabetic effects of bitter gourd reported in the
literature and discusses what still needs to be clarified for developing an evidence-based and safe use of the bitter gourd
for diabetes. Analyses of bioactive compounds have shown that bitter gourd is rich in nutrients and phytochemicals of
which some have anti-diabetic effects. Juices, powders, extracts, and isolated compounds have been tested in vitro and in
vivo. Bitter gourd increases insulin secretion of the pancreas, decreases intestinal glucose uptake, and increases uptake and
utilization of glucose in peripheral tissues. Although human studies with type 2 diabetics are weak in their design and/or
results, some of the studies do indicate anti-diabetic effects in patients and safety for bitter gourd treatment in humans. In
the future, well designed studies with rodents will help to understand what kind of bitter gourd variety, dosage, preparation,
and duration of administration is optimal. Such results will help to design human studies which are necessary to
prove the effectiveness of bitter gourd in patients.
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