Recently Patented Transcatheter Aortic Valves in Clinical Trials
Siyamek Neragi-Miandoab, Edvard Skripochnik, Arash Salemi and Leonard Girardi
Affiliation: Department of Cardiothoracic Surgery, Cornell University Medical Center, Weil Cornell College of Medicine, 525 68th street, New York, NY 10065, USA.
The most widely used heart valve worldwide is the Edwards Sapien, which currently has 60% of the worldwide
transcatheter aortic valve implantation (TAVI) market. The CoreValve is next in line in popularity, encompassing 35% of
the worldwide TAVI market. Although these two valves dominate the TAVI market, a number of newer transcatheter
valves have been introduced and others are in early clinical evaluation. The new valves are designed to reduce catheter delivery
diameter, improve ease of positioning and sealing, and facilitate repositioning or removal. The most recent transcatheter
valves for transapical use include Acurate TA (Symetis), Engager (Medtronic), and JenaValve the Portico (St
Jude), Sadra Lotus Medical (Boston Scientific), and the Direct Flow Medical. These new inventions may introduce more
effective treatment options for high-risk patients with severe aortic stenosis. Improvements in transcatheter valves and the
developing variability among them may allow for more tailored approaches with respect to patient's anatomy, while giving
operators the opportunity to choose devices they feel more comfortable with. Moreover, introducing new devices to
the market will create a competitive environment among producers that will reduce high prices and expand availability.
The present review article includes a discussion of recent patents related to Transcatheter Aortic Valves.
Keywords: Direct flow medical, jenavalve, medtronic engager, portico aortic valve, self-expanding valves, symetis, sadra
medical, transcatheter aortic valve implantation, transapical approach, transfemoral approach.
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