An Efficient Synthesis of Some New Hydrazone Derivatives Containing 1,2,3-Triazole and Thiazole

Author(s): Keyume Ablajan, Wang Liju, Anagu Tuoheti.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 10 , 2013

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Abstract:

The syntheses of hydrazone derivatives with thiazole and triazole rings were described. The target compounds 7a-j and 8a-g with the hydrazine based structure containing thiazole and triazole rings were synthesized respectively through the reactions of α-bromomethylpyrazole ketone 3 with arylethanone thiosemicarbazones 5a-j and the reactions of pyrazol thiosemicarbazone 4 with α-bromomethyl aryl ketones 6a-g under reflux condition without catalyst. Furthermore, an eco-friendly convenient method for the synthesis of compounds 8a-g was developed using one-pot route. The target compounds were tested for preliminary bioactivities by using H2O2-induced PC 12 cells with oxidative injury.

Keywords: 1, 2, 3-Triazole, thiazole, hydrazone, synthesis, one-pot reaction, bioactivity.

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Article Details

VOLUME: 10
ISSUE: 10
Year: 2013
Page: [715 - 721]
Pages: 7
DOI: 10.2174/157017861010131126115715
Price: $65

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