The syntheses of hydrazone derivatives with thiazole and triazole rings were described. The target compounds
7a-j and 8a-g with the hydrazine based structure containing thiazole and triazole rings were synthesized respectively
through the reactions of α-bromomethylpyrazole ketone 3 with arylethanone thiosemicarbazones 5a-j and the reactions of
pyrazol thiosemicarbazone 4 with α-bromomethyl aryl ketones 6a-g under reflux condition without catalyst. Furthermore,
an eco-friendly convenient method for the synthesis of compounds 8a-g was developed using one-pot route. The target
compounds were tested for preliminary bioactivities by using H2O2-induced PC 12 cells with oxidative injury.
Keywords: 1, 2, 3-Triazole, thiazole, hydrazone, synthesis, one-pot reaction, bioactivity.
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